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Is pimecrolimus the same as tacrolimus? Tacrolimus is manufactured as 0.03% and 0.1% ointment while pimecrolimus is distributed as a 1% cream. Each agent has been FDA approved for short and long-intermittent treatment of atopic dermatitis in children as young as 2 years of age.
Is tacrolimus nephrotoxic? The molecular basis of cyclosporine and tacrolimus nephrotoxicity is less well understood, but there is evidence that it may be mediated by the calcineurin pathway as well. Thus, cyclosporine and tacrolimus binding proteins are present at a high concentration in the kidney (higher than in the liver and spleen).
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