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How do you use an estrogen patch? PLACE. Using the other half of the liner as a handle, apply Minivelle (estradiol transdermal system) below your waistline (either below to your lower abdomen OR buttocks). Do not apply patch to your breasts. Avoid touching the sticky half of the patch with your fingers. Where do you apply Sandrena gel? Sandrena gel should be applied each day to a clean, dry, unbroken, non-irritated area of skin on the lower trunk or thigh. Use the right and left sides of the body on alternate days. Spread the prescribed amount of gel over an area of skin one to two times the size of your hand.
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