What are the most common side effects of losartan? Common losartan side effects may include: cold or flu symptoms such as stuffy nose, sneezing, sore throat, fever; dry cough; muscle cramps; pain in your legs or back; stomach pain, diarrhea; headache, dizziness; tired feeling; or. sleep problems (insomnia). Should you take losartan in the morning or night? To keep this medication from disturbing your sleep, consult with your doctor regarding the possibility of taking your dose early in the day. Losartan may be taken with or without food. It may take up to three to six weeks of using this medication before your blood pressure is under control. When should you take blood pressure medicine morning or night? When to take medicine : Take at least one blood pressure -lowering medication at bedtime. Drugs called ACE inhibitors and ARBs are the most effective when taken at this time.
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